TL;DR
Philadelphia has some of the best in-person PrEP access in the country. Your fastest options: Philadelphia Department of Public Health clinics (walk-in, regardless of insurance), PrEP2Me (completely free TelePrEP for PA residents, PA DOH-funded), Mazzoni Center (LGBTQ+ FQHC with 15,000+ patients/year), and Philadelphia FIGHT (the oldest and largest PrEP program in the city, since 2012). All four cost $0 for most people. MISTR works too if you want discreet, mail-order telehealth.
The Philadelphia HIV picture
Philadelphia's HIV prevalence rate (1,157 per 100,000) is nearly four times the Pennsylvania state rate, and Black Philadelphians — 43% of the population — represent 64% of people living with HIV. The city has responded with an exceptionally dense PrEP provider network and — critically — a state-funded free TelePrEP program. Philadelphia doesn't have a state PrEP-DAP to fall back on like New York does, but the city-level infrastructure is arguably stronger than anywhere else in the Northeast outside of NYC.
Your fastest paths to $0 PrEP in Philadelphia
- PrEP2Me (TelePrEP) — PA DOH-funded, completely free for PA residents. Operated by Central Outreach Wellness Center (Pittsburgh) but serves the entire state. Call 412-844-PREP or visit prep2me.com.
- Philadelphia Department of Public Health clinics — PrEP at all city health centers regardless of insurance status. Five locations: 1930 S. Broad, 1700 S. Broad, 555 S. 43rd, 4400 Haverford Ave, 1900 N. 20th.
- Philadelphia FIGHT — The first and largest PrEP program in Philadelphia (since 2012). Same-day PrEP starts, virtual visits with at-home testing. Call 215-545-PREP (7737).
- Mazzoni Center — LGBTQ+ FQHC, 15,000+ patients/year. PrEP, HIV/STI testing, and trans healthcare all in one place. 1348 Bainbridge St. Call 215-985-9206.
- MISTR telehealth — $0 everything, shipped in unmarked packaging. Works for insured and uninsured alike.
Start PrEP today from anywhere in Philadelphia
MISTR serves all of Philadelphia — Center City, South Philly, West Philly, Fishtown, Northern Liberties, the Northeast, and everywhere in between. $0 medication, labs, and consults. If you'd rather not visit a clinic in person, this is your fastest path.
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Using this code helps keep FreePrEP.org running and connects more people to free PrEP.
Start with MISTR →Pennsylvania state programs that pay for PrEP
Pennsylvania does NOT have a state PrEP Drug Assistance Program. The Special Pharmaceutical Benefits Program (SPBP) only covers HIV treatment, not prevention. Its income threshold was actually lowered from 500% to 350% FPL in October 2025 due to budget pressure.
What Pennsylvania does offer: PrEP2Me. This is a PA DOH-funded, completely free TelePrEP program available to any PA resident. It's operated by Central Outreach Wellness Center in Pittsburgh but serves the whole state. Call 412-844-PREP or visit prep2me.com.
Pennsylvania Medicaid (Medical Assistance) covers PrEP at $0. PA expanded Medicaid in 2015. Apply via COMPASS at compass.state.pa.us or call the DHS HelpLine at 1-800-692-7462.
PA State AIDS Fact Line: 1-800-662-6080 for general PrEP navigation.
Looking for the full Pennsylvania guide?
We have a dedicated page with every clinic, program, and telehealth option across the state.
Key clinics in Philadelphia
One of the largest LGBTQ+ health centers in the Northeast. 15,000+ patients per year. PrEP, free HIV/STI testing, trans healthcare. Sliding-fee scale and 340B pricing means most people pay $0.
The first dedicated PrEP program in Philadelphia and still the largest. Same-day PrEP starts, virtual visits with at-home testing, integrated care for insured and uninsured patients.
PrEP at all city health centers regardless of insurance. Walk-in options. Locations: 1930 S. Broad St, 1700 S. Broad St, 555 S. 43rd St, 4400 Haverford Ave, 1900 N. 20th St.
Adolescent and young adult PrEP services. Critical resource for Philly teens under 18 who want PrEP confidentially.
Free HIV testing, PrEP, and AHF Pharmacy. Walk-in friendly.
PrEP services at the Elizabeth Blackwell Health Center in Center City, plus multiple other locations around the metro.
Telehealth options for Philadelphia residents
Philadelphia telehealth is unusually strong because Pennsylvania operates PrEP2Me — a completely free, state-funded TelePrEP program. Combined with national platforms like MISTR, you have excellent online options.
MISTR covers medication, quarterly lab work, consultations, and delivery at $0 in all 50 states. Works for insured and uninsured patients alike. Oral and injectable PrEP available. First prescription typically in 24–48 hours.
Completely free TelePrEP for Pennsylvania residents. Operated by Central Outreach Wellness Center (Pittsburgh), state-funded through PA DOH. Serves PA, OH, and WV.
Not sure which path is right for you?
Use our eligibility tool — four questions, 60 seconds, no sign-up. We'll match you with every free PrEP program you qualify for in Pennsylvania.
Start the Eligibility Tool →Special situations in Philadelphia
If you're a minor
Pennsylvania law allows minors of any age to consent to STI/HIV testing and treatment without parental permission. A federal court has interpreted this to include HIV prevention services — meaning PrEP. St. Christopher's Hospital is Philadelphia's go-to youth PrEP resource (ages 13–24). See our PrEP as a Minor guide.
If you're undocumented
FQHCs like Mazzoni Center and Philadelphia FIGHT serve everyone regardless of immigration status. Gilead Advancing Access accepts undocumented patients with no SSN required. MISTR doesn't require documentation. See our PrEP for Undocumented Immigrants guide.
If you're transgender
Mazzoni Center is one of the most established trans-affirming healthcare providers in the Northeast — HRT and PrEP from the same clinic. See our PrEP for Transgender Women guide.
If you need PEP instead
If you've had a potential HIV exposure in the last 72 hours, you need PEP, not PrEP. Philadelphia ERs can prescribe PEP — Jefferson, Penn Medicine, Temple, and Einstein all have protocols. Philadelphia FIGHT also offers rapid PEP access through its telehealth line (215-545-PREP). State clearly: "I had a potential HIV exposure in the last 72 hours and need PEP." After your 28-day PEP course, your provider should transition you to PrEP for ongoing protection — see our How to Get PEP guide.
Bottom line
Philadelphia is one of the easiest cities in the country to get free PrEP. Between PrEP2Me (state-funded free TelePrEP), the Philadelphia Department of Public Health clinic network, Mazzoni Center, and Philadelphia FIGHT, every Philly resident has multiple $0 pathways available. If you want the absolute fastest: call PrEP2Me or use MISTR. If you want in-person LGBTQ+-affirming care: Mazzoni. If you want the most experienced PrEP program: FIGHT.
Ready to start PrEP?
MISTR ships to anywhere in Philadelphia and the rest of Pennsylvania. $0 medication, labs, and consults — insured or not.
ANDR735
Using this code helps keep FreePrEP.org running and connects more people to free PrEP.
Get Started with MISTR →