MISTR vs. Freddie vs. Q Care Plus: Which Free PrEP Telehealth Is Best?
Three telehealth platforms offer $0 PrEP — but they work differently, serve different populations, and cover different states. Here's an honest head-to-head comparison to help you choose.
Quick Comparison
| MISTR | Freddie | Q Care Plus | |
|---|---|---|---|
| Cost | $0 | $0 for most | $0 for 99% insured |
| States | 50 + DC + PR | 50 states | Select states |
| At-home labs | Yes | Yes | Yes |
| Uninsured access | Yes — $0 | Yes — $0 for most | CBO partnerships |
| Injectable PrEP | Enrolling (Yeztugo) | Coming soon | Not yet |
| Model | 340B partnerships | Insurance + PAP nav | 340B/CBO partnerships |
| Gender-affirming care | Yes | Men/transmasc only | Yes |
| Patients served | 500,000+ | Not published | Not published |
MISTR
Best for: Most people — especially uninsured or rural
MISTR is the largest telehealth PrEP platform in the U.S., serving over 500,000 patients through 340B community health partnerships. Everything is $0 — consultations, at-home labs, medication, and delivery — regardless of insurance status. MISTR is enrolling patients for Yeztugo (twice-yearly injectable) and serves all genders.
Strengths: True $0 for everyone, nationwide coverage, at-home everything, largest platform with the most established track record, injectable PrEP pipeline.
Limitations: Some users report slow onboarding during high-demand periods. The 340B model means MISTR defaults to brand Descovy (higher 340B margin) rather than generic — though you can request generic.
Freddie
Best for: Cisgender men and transmasculine individuals
Freddie expanded to all 50 states through a partnership with the American Sexual Health Association (ASHA). The platform provides $0 PrEP for the majority of patients through a combination of insurance billing and manufacturer patient assistance program navigation. At-home lab kits and discreet medication delivery are included.
Strengths: Clean, streamlined experience. Nationwide coverage. Strong patient education resources.
Limitations: Currently serves men and transmasculine individuals only — not available for cisgender women or transfeminine patients. The 340B model is not confirmed, which may limit $0 access for some uninsured patients compared to MISTR.
Q Care Plus
Best for: Insured patients in covered states, especially LGBTQ+ individuals
Q Care Plus operates through community-based organization (CBO) partnerships, similar to MISTR's 340B model. The platform reports $0 cost for 99% of insured patients. Q Care Plus also offers gender-affirming care alongside PrEP, making it a strong choice for transgender patients who want integrated services.
Strengths: Strong gender-affirming care. CBO partnerships ensure community-rooted care model. $0 for most insured patients.
Limitations: Not available in all states — check qcareplus.com for current coverage. Uninsured access depends on CBO partnership availability in your area. No public patient count or track record data.
FreePrEP.org Recommendation
For most people, start with MISTR. It's the only platform that's truly $0 in all 50 states for both insured and uninsured patients, with the largest user base and most established 340B infrastructure. If you're a cisgender man who prefers Freddie's interface, it's an equally valid choice. If you're in a state where Q Care Plus operates and want integrated gender-affirming care, it's an excellent option.
The good news: all three are free. Try the one that fits your situation — you can always switch.
Try MISTR — $0 PrEP in all 50 states
Free consultations, at-home labs, medication, and delivery. Works with or without insurance through 340B community health partnerships.
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Other Telehealth PrEP Options
Nurx: Charges a $15–$30 consultation fee plus lab costs. Nurx's parent company is pivoting away from PrEP toward women's health, making it an unreliable long-term option. Available in ~36 states.
PlushCare: Charges $99–$129 per consultation plus membership fees. Requires in-person lab visits. Not PrEP-specialized. Available in most states but significantly more expensive than the three platforms above.
FOLX Health: LGBTQ+-focused membership-based platform available in all 50 states. Offers PrEP alongside hormone therapy and other services. Membership-based pricing rather than $0 model.