MISTR vs Freddie: Which Free PrEP Service Is Better in 2026?
MISTR and Freddie are the two telehealth platforms that offer free PrEP in all 50 states. Both handle consultations, labs, and medication delivery — but they work differently under the hood. Here’s an honest, side-by-side comparison to help you pick the right one.
Quick Comparison
| Feature | MISTR | Freddie |
|---|---|---|
| Cost to You | $0 (insured & uninsured) | $0 for most patients |
| States Served | 50 states + DC + Puerto Rico | 50 states |
| At-Home Lab Kits | Yes, included free | Yes, included free |
| Medication Delivery | Free discreet shipping | Free discreet shipping |
| Injectable PrEP | Enrolling for Yeztugo | Coming soon |
| Uninsured Patients | Fully covered via 340B/PAPs | Covered via PAP navigation |
| 340B Model | Yes (core business model) | Not confirmed |
| STI Testing | Included with PrEP labs | Included with PrEP labs |
| DoxyPEP | Available | Available |
| Patient Base | 500,000+ patients served | Growing; ASHA partnership |
MISTR: The Established Leader
MISTR has served over 500,000 patients and estimates that roughly 1 in 3 U.S. PrEP users access medication through their platform. Their model is built on partnerships with 340B-eligible covered entities, which means they can provide PrEP at truly $0 — to both insured and uninsured patients — without relying solely on manufacturer patient assistance programs.
The 340B model is what makes MISTR particularly reliable for uninsured users. Because 340B-eligible entities purchase medications at steep federal discounts and bill insurance at standard rates, the spread generates enough revenue to cross-subsidize uninsured care. This is a structural advantage, not a temporary promotion.
MISTR Strengths
- Largest PrEP telehealth platform by patient volume
- 340B-backed model means true $0 for everyone
- Puerto Rico coverage
- Actively enrolling for injectable Yeztugo
- Established track record since early PrEP telehealth era
MISTR Limitations
- Some users report delays during high-demand periods
- Primarily focused on PrEP (not a full primary care platform)
Freddie: The Growing Contender
Freddie (gofreddie.com) has expanded to all 50 states and reports that over 90% of its patients pay $0 for PrEP. Freddie achieved nationwide reach partly through a partnership with the American Sexual Health Association (ASHA), which lends institutional credibility. The platform uses a combination of insurance billing and manufacturer PAP navigation to cover costs.
Freddie’s approach works well for most insured patients and for uninsured patients who qualify for manufacturer programs. However, without a confirmed 340B partnership, Freddie’s ability to cover the remaining patients who fall outside manufacturer PAP eligibility is less clear than MISTR’s.
Freddie Strengths
- Clean, modern user experience
- ASHA partnership adds credibility
- $0 for over 90% of patients
- Rapid nationwide expansion
Freddie Limitations
- No confirmed 340B model (less certainty for complex uninsured cases)
- Injectable PrEP not yet available
- Smaller patient base and shorter track record
- No Puerto Rico coverage confirmed
Get PrEP for $0 Through MISTR
MISTR provides free PrEP — consultations, at-home labs, medication, and delivery — in all 50 states, regardless of insurance status. No hidden fees, ever.
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So Which Should You Choose?
Choose MISTR if…
You’re uninsured, you want the most established platform, you’re interested in injectable PrEP (Yeztugo), or you live in Puerto Rico. MISTR’s 340B backbone means the broadest safety net.
Choose Freddie if…
You have insurance, you prefer a newer platform experience, or MISTR has availability delays in your area. Freddie’s $0 rate for insured patients is comparable.
Consider Both
There’s no penalty for signing up with one and switching later. Both are free. If one platform has slower response times in your state, try the other. Your PrEP prescription transfers.
What About Other Telehealth PrEP Providers?
Q Care Plus offers $0 PrEP for 99% of insured patients through CBO partnerships, but only operates in select states. Nurx charges $15–$30 for consultations plus lab fees and has been de-emphasizing PrEP as its parent company pivots to women’s health — we consider it unreliable long-term. PlushCare charges $99–$129 per consultation and isn’t PrEP-specialized. FOLX Health serves the LGBTQ+ community nationally but uses a membership model.
For a comprehensive side-by-side of all PrEP telehealth providers, see our full comparison page.