TL;DR
SF free PrEP options: SF City Clinic (DPH-operated, walk-in, free regardless of insurance or status); Strut at SF AIDS Foundation (Castro location, LGBTQ+-focused); UCSF 360 Wellness Center; California PrEP-AP (statewide, ≤500% FPL, serves undocumented); Medi-Cal (full-scope coverage regardless of immigration status); and telehealth platforms for $0 delivery.
San Francisco's HIV landscape
San Francisco has the highest per-capita HIV prevalence rate in California, though the city's aggressive prevention and treatment efforts have dramatically reduced new infections over the past decade. SF's Getting to Zero initiative has driven national best practices. Federal funding pressure in 2025-2026 has been hard on SF providers — SF AIDS Foundation lost ~$500K in CDC grants and laid off 34 positions in June 2025; SF DPH lost $8M+ in federal funding. Core PrEP access has been preserved but the ecosystem is strained.
Three main pathways to free PrEP in San Francisco
Pathway 1: SF City Clinic (SFDPH)
San Francisco's flagship public sexual health clinic — operated by the SF Department of Public Health. Provides free PrEP, PEP, HIV testing, and STI services regardless of insurance status.
- Address: 356 7th St, San Francisco CA 94103
- Phone: (628) 217-6600
- Services: Free walk-in PrEP evaluation, same-day STI testing, PEP, HIV testing
- No insurance or documentation required
Pathway 2: Strut (SF AIDS Foundation)
Strut is SF AIDS Foundation's sexual health center in the Castro — the first LGBTQ+-focused sexual health space in SF. Provides PrEP, testing, substance use counseling, and mental health services.
- Address: 470 Castro St, San Francisco CA 94114
- Phone: (415) 581-1600
- Services: PrEP, STI testing, mental health, substance use support; free regardless of insurance
- Website: sfaf.org/services/strut
Pathway 3: Online telehealth platforms
Online telehealth platforms like MISTR provide free PrEP delivered to any San Francisco address — including consultation, labs, and medication — regardless of insurance status. For many San Francisco residents, this is the fastest path to $0 PrEP, especially for people who prefer privacy or can't make a daytime clinic appointment.
Get free PrEP delivered anywhere in San Francisco
MISTR operates across all of California — PrEP delivered to your San Francisco address with no clinic visit required. Free consultation, free labs (at-home or local), and discreet home delivery.
Start free consultation →ANDR735
Using this code helps keep FreePrEP.org running at no cost to you. MISTR's $0 PrEP is funded through insurance reimbursement and 340B program partnerships — you pay nothing whether you have insurance or not.
San Francisco-area providers to know
UCSF 360 Wellness Center
PrEP, primary care, and specialty HIV services through UCSF. Accepts most insurance and provides sliding-scale for uninsured. hiv.ucsf.edu/360
Lyon-Martin Community Health Services
Trans-affirming care including PrEP. Long-standing provider serving SF's transgender community. lyon-martin.org
San Francisco Community Health Center
Formerly API Wellness — PrEP for Asian/Pacific Islander communities and broader service. Phone: (415) 292-3400.
Planned Parenthood Mar Monte
Multiple Bay Area locations with PrEP services. Accepts Medi-Cal and provides sliding-scale for uninsured. plannedparenthood.org/planned-parenthood-mar-monte
State-level programs and links
San Francisco residents benefit from California's broader PrEP infrastructure. For state-level programs, eligibility details, and statewide resources, see our California PrEP guide or the complete state-by-state directory.
California-specific advantages for SF residents: Full-scope Medi-Cal is available to all California residents regardless of immigration status. PrEP-AP is the largest state PrEP program in the country (~11,746 projected enrollees in FY 2025-26). Pharmacist PrEP prescribing is authorized statewide (SB 159/SB 339). California has the most EHE priority jurisdictions of any state.
Skip the clinic wait — get PrEP delivered in San Francisco
MISTR ships free PrEP to San Francisco addresses in 3–5 days. Great option for San Francisco residents who want privacy or can't fit a clinic visit into their schedule.
Get started with MISTR →ANDR735
Special populations in San Francisco
If you're undocumented: California has the most inclusive policies in the country. Full-scope Medi-Cal regardless of immigration status. PrEP-AP serves regardless of status. SF City Clinic serves everyone without documentation requirements. Gilead Advancing Access is available without SSN requirement.
If you're a minor: California law allows minors 12+ to consent to STI prevention services, including PrEP. SF City Clinic serves minors with confidential care.
If you're transgender: California has strong nondiscrimination protections. Lyon-Martin has served SF's trans community for decades with trans-affirming PrEP care.
Not sure which San Francisco option is right for you?
A free MISTR consultation can help you decide. If telehealth works, MISTR handles everything. If you need in-person care, they can direct you to the right San Francisco provider.
Get started with MISTR →ANDR735
Frequently asked questions
How do I get free PrEP at SF City Clinic?
Walk into SF City Clinic (356 7th St) during operating hours or call (628) 217-6600. Free PrEP evaluation regardless of insurance or documentation status.
Can I get free PrEP in San Francisco if I'm undocumented?
Yes. Full-scope Medi-Cal is available regardless of immigration status. PrEP-AP serves undocumented residents. SF City Clinic, Strut, and community providers serve everyone. Gilead Advancing Access doesn't require a Social Security Number.
What's Strut at SF AIDS Foundation?
Strut is SF AIDS Foundation's LGBTQ+-focused sexual health center in the Castro (470 Castro St). Provides free PrEP, testing, mental health, and substance use services. LGBTQ+-affirming by design.
Is MISTR available in San Francisco?
Yes. MISTR operates statewide in California with delivery to any SF address. Free consultation and labs, with discreet medication delivery.
Has federal funding affected SF PrEP access?
Yes, significantly. SF AIDS Foundation lost ~$500K in CDC grants in 2025; SF DPH lost $8M+ in federal funding. Core PrEP access has been preserved but wait times and program availability may be more limited than 2022-2024 levels.
Can I use California PrEP-AP if I live in SF?
Yes. PrEP-AP is a statewide program covering medication, labs, and clinic visits for California residents under 500% FPL regardless of immigration status. SF has many PrEP-AP-enrolled providers including SF AIDS Foundation.